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目的：研究宫颈腺癌(uterine cervix adenocarcinoma)合并宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)的临床与病理特征,并探讨P16蛋白、Ki-67蛋白在宫颈腺癌组织或CIN病变组织中的表达。方法对4例宫颈腺癌合并CIN进行液基细胞学、组织学和免疫组织化学检查,并复习国内外相关的文献。结果4例宫颈腺癌合并CIN均发生于中年女性,液基细胞学检查结果提示非典型腺上皮细胞(AGC)伴高级别鳞状上皮内瘤变(HSIL),其中3例宫颈活检提示宫颈腺癌伴发CIN3,仅有1例为宫颈腺癌伴早期浸润性鳞状细胞癌。免疫组化：P16、Ki-67蛋白在肿瘤、高级别病变组织均呈阳性。结论宫颈腺癌合并CIN是发生率非常低的宫颈恶性肿瘤,其中液基细胞学的检查有助于宫颈肿瘤的早期发现,P16、Ki-67蛋白的辅助检测有助于宫颈肿瘤的确诊。“,”Objective The aim of this study is to investigate the clinical and pathological characteristics of uterine cervix adenocarcinoma with cervical intraepithelial neoplasis,as wel as the expression of protein P16 and Ki-67 in cervical adenocarcinoma tissues and CIN. Methods 4 cases of uterine cervix adenocarcinoma with CIN were examined by liquid based cytology,histological and the immunohistochemistry,and the pertinent literatures were reviewed.Results 4 cases of uterine cervix adenocarcinoma with CIN al existed in middle-aged women and the liquid based cytology examination found out the atypical sex gland epithelial cel s (AGC)with high grade squarmous intraeptithelial neoplasia(HSIL).3 cases of cervical biopsy show uterine cervix adenocarcinoma with CIN3, and only 1 case was the uterine cervix adenocarcinoma with early invasive squamous carcinoma.Immunohistochemical testing show the expression of protein P16 and Ki-67 in diseased tissues were positive.Conclusion Uterine cervix adenocarcinoma with CIN is a rare cervical malignant tumor,and the liquid based cytology examination can help find the cervical tumours early. Protein P16 and Ki-67 can make a definite diagnosis of cervical tomours.