【摘 要】
：
AIM:To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model.METHODS:Rats were randomly assi
【机 构】
：
Department of Surgery,Department of Microbiology,Department of Pathology,Department of Biochemistry
论文部分内容阅读
AIM:To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerative colitis model.METHODS:Rats were randomly assigned to three groups:group Ⅰ:control,group Ⅱ: experimental colitis,group Ⅲ:colitis plus melatonin treatment.On d 11 after colitis,plasma tumor necrosis factor-α,portal blood endotoxin levels,colon tissue myeloperoxidase and caspase-3 activity were measured.Bacterial translocation was quantified by blood,lymph node,liver and spleen culture.RESULTS:We observed a significantly reduced incidence of bacterial translocation to the liver,spleen,mesenteric lymph nodes,portal and systemic blood in animals treated with melatonin.Treatment with melatonin significantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-treated rats (16.11 ± 2.46 vs 32.97 ± 3.91,P ＜ 0.01).CONCLUSION:Melatonin has a protective effect on bacterial translocation and apoptosis.
其他文献
End stage liver disease (ESLD) is a health problem worldwide. Liver transplantation is currently the only effective therapy, but its many drawbacks include a sh
AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of i
Alterations of normal function of interstitial cells of Cajal (ICC) are reported in many intestinal disorders. Diagnosis of their involvement is rare (infrequen
Lymphoepitelioma is a particular form of undifferentiat-ed carcinoma, characterized by a prominent lymphoid stroma, originally described in the nasopharynx. Lym
Colorectal cancer(CRC)remains a leading cancer killer worldwide.But the disease is both curable and preventable at an early stage.Regular CRC cancer screening h
Acute acalculous cholecystitis (AAC) is defined as an acute inflammation of the gallbladder in the absence of stones. We herein report a case of a young man who
Ghrelin was isolated as an endogenous ligand for the GH secretagogue receptor from the rat stomach. Although physiological effects of ghrelin have been revealed
Retroperitoneal tumors are difficult to distinguish,especially because they share common radiological features with tumors of the liver.1 When we come across su
Acute myeloid leukemia (AML) M4Eo type is a hematological malignancy with abnormal eosinophilia,which is often accompanied by inv(16).The Ets variant gene 6 (ET