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抗原表达的异质性是人肿瘤细胞的特征,大大影响了单克隆抗体(McAb)的诊断和治疗应用。自然重组的人干扰素除具有激发抗病毒和抗增殖活性外,在体内外均能改变人各种肿瘤细胞表面抗原的表型。重组人白细胞干扰素(Hu-IFN-α)能促使HLA抗原的表达,增加数种McAb确定的人乳腺癌和结肠癌细胞表面肿瘤抗原。用RIA、荧光流式细胞分离器和
Heterogeneity of antigen expression is characteristic of human tumor cells, greatly affecting the diagnostic and therapeutic applications of monoclonal antibodies (McAbs). Naturally recombinant human interferon, in addition to having antiviral and antiproliferative activities, alters the phenotype of human tumor cells’ surface antigens both in vitro and in vivo. Recombinant human leukocyte interferon (Hu-IFN-α) can promote the expression of HLA antigens and increase the surface antigens of human breast cancer and colon cancer cells identified by several McAbs. Use RIA, a fluorescent flow cytometer and