【摘 要】
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Metal nanoparticles have been used as antibacterial agents widely,and the combined use of enzymes and metal nanoparticles promotes antibacterial activity,achieving a synergistic effect.Additionally,enzymes decrease the amounts of metals and increase bioco
【机 构】
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Key Lab for Industrial Biocatalysis,Ministry of Education,Department of Chemical Engineering,Tsinghu
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Metal nanoparticles have been used as antibacterial agents widely,and the combined use of enzymes and metal nanoparticles promotes antibacterial activity,achieving a synergistic effect.Additionally,enzymes decrease the amounts of metals and increase biocompatibility,thereby reducing toxicity of metals.How-ever,the efficiency of enzymes is hindered when coupled with metals,which causes deactivation in the function of enzymes.How can a balance be struck between metals and enzymes?Although the antibac-terial mechanism of metal nanoparticles is relatively clear,how enzyme-metal nanocomposites work against bacteria is not conclusive.Here,we describe several examples on the synthesis of enzyme-metal nanocomposites via co-immobilization or in situ reduction and summarize how enzyme-metal nanocom-posites combat microorganisms.
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