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目的探讨急性氟乙酰胺中毒致胼胝体变性(MBD)的临床特点及治疗对策。方法 回顾性分析本院收治的1例急性氟乙酰胺中毒致MBD患者的临床资料。结果 本例氟乙酰胺中毒患者以急性中毒起病,出现面具脸、言语含糊、肌张力增高、四肢静止性震颤、共济失调等症状,在使用特效解毒剂的基础上,应用糖皮质激素冲击、高压氧、B族维生素、抗震颤等综合治疗后,症状减轻。结论 急性氟乙酰胺中毒出现言语障碍、帕金森综合征样症状与共济失调等时应考虑MBD的可能,早期通过影像学检查明确诊断,尽早采取积极的治疗措施可取得一定的疗效。
Objective To investigate the clinical characteristics and treatment of corpus callosum degeneration (MBD) caused by acute fluoroacetamide intoxication. Methods The clinical data of 1 MBD patients with acute fluoroacetamide poisoning admitted to our hospital were retrospectively analyzed. Results In this case, patients with fluoroacetamide poisoning onset acute poisoning, there mask face, verbal ambiguity, increased muscle tension, rest tremor limbs, ataxia and other symptoms, the use of special antidote, based on the application of corticosteroid shock , Hyperbaric oxygen, B vitamins, anti-tremor and other comprehensive treatment, reduce the symptoms. Conclusion Acute fluoroacetamide poisoning appears speech disorder, Parkinson’s syndrome-like symptoms and ataxia should consider the possibility of MBD, early clear diagnosis by imaging examination, as soon as possible to take positive treatment measures can achieve a certain effect.