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目的观察多西紫杉醇周疗联合小剂量顺铂治疗晚期非小细胞肺癌的疗效及毒副反应。方法对2005年7月至2007年10月哈尔滨医科大学附属第二医院经病理证实的76例非小细胞肺癌患者进行多西紫杉醇周疗+小剂量顺铂联合化疗。结果76例患者中部分缓解32例,稳定25例,进展19例,总有效率为42.1%。初治组有效率为46.3%,复治组有效率为37.1%。最常见的毒副反应为骨髓抑制,毒副反应均可耐受。结论多西紫杉醇周疗联合小剂量顺铂治疗非小细胞肺癌有较好的疗效,毒性反应小可以耐受,具有较好应用价值。
Objective To observe the efficacy and side effects of docetaxel combined with low-dose cisplatin in the treatment of advanced non-small cell lung cancer. Methods From July 2005 to October 2007, 76 patients with non-small cell lung cancer confirmed by pathology in the Second Affiliated Hospital of Harbin Medical University were treated with docetaxel plus low-dose cisplatin combined with chemotherapy. Results Of the 76 patients, 32 were partially relieved, 25 were stable, and 19 were advanced. The total effective rate was 42.1%. The effective rate of the initial treatment group was 46.3% and that of the retreatment group was 37.1%. The most common side effects of bone marrow suppression, toxicity can be tolerated. Conclusion Docetaxel weekly combined with low-dose cisplatin treatment of non-small cell lung cancer has a good effect, toxicity can be tolerated small, with good value.