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目的:研究运动对2型糖尿病患者下肢经皮氧分压(tcpO2)的影响,以探索运动时的tcpO2动态变化对糖尿病患者循环障碍的诊断价值。方法:用踩踏功率自行车运动干预方法观察了12例2型糖尿病患者(24条下肢)以及3名正常成人(6条下肢)腓肠肌tcpO2的变化情况,同时检测静息状态下的踝肱比(ABI)和定量振动阈值(QST)。根据患者ABI水平将患者肢体分成>0.9而≤1.3亚组、0.7~0.9亚组和<0.7亚组3组,比较分析各组tcpO2变化情况。结果:所有糖尿病患者的tcpO2水平在运动过程中均出现下降趋势,而正常组则出现上升趋势。在静息状态下,tcpO2运动前后的变化值与ABI呈线性相关,但与QST并无线性关系。在ABI>0.9而≤1.3亚组tcpO2在运动早期出现轻度升高,但随即下降到基础水平;在ABI为0.7~0.9亚组,tcpO2在运动初期即出现下降;在ABI<0.7亚组则出现快速下降。结论:在运动中测量tcpO2水平有助于对糖尿病患者微循环储备功能的判断。
Objective: To study the effect of exercise on the transcutaneous oxygen tension (tcpO2) of lower extremities in type 2 diabetic patients and to explore the diagnostic value of dynamic changes of tcpO2 during exercise in patients with circulatory disturbance of diabetes mellitus. Methods: The changes of tcpO2 in gastrocnemius muscle of 12 patients with type 2 diabetes mellitus (24 lower extremities) and 3 normal adults (6 lower extremities) were observed by using stamina power cycling intervention. At the same time, resting ankle-brachial ratio (ABI ) And quantitative vibration threshold (QST). The patients’ limbs were divided into three groups of> 0.9 and ≤1.3 subgroups, 0.7 ~ 0.9 subgroups and <0.7 subgroups according to the ABI level of patients. The changes of tcpO2 in each group were compared. Results: The level of tcpO2 in all diabetic patients showed a downward trend during exercise, while the normal group showed an upward trend. In rest state, the change of tcpO2 before and after exercise was linearly correlated with ABI, but not with QST. In the group of ABI> 0.9 and ≤1.3, tcpO2 slightly increased in the early stage of exercise, but then decreased to the basal level. In the group of ABI 0.7-0.9, tcpO2 decreased in the early stage of exercise, while in the group of ABI <0.7 A rapid decline appears. CONCLUSIONS: Measuring tcpO2 level during exercise contributes to the judgment of microcirculation reserve function in diabetic patients.