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Stable oxygen isotopes in precipitation contain meaningful environmental information on a synoptic scale and can be applied to diagnose hydrometeorological processes. A series of rainstorms occurred at the south Tianshan Mountains during the period from May to June 2013, and the event-based precipitation was sampled along the mountain range from west to east. Based on δ18O values in precipitation samples as well as the corresponding meteorological parameters, the moisture transport paths during the sampling period were identified. In late-May (stage 1), isotopes in precipitation collected generally showed a depleting trend. In mid-June (stage 2), there was no coherent trend of isotopes in precipitation for these stations, and only isotope values in Aksu showed a continually depleting trend. Checking other meteorological proxies during the sampling period, the event-based precipitation isotopes sensitively reflected the moisture process. In central Asia, both the westerly and monsoon moisture can be delivered to cause extreme precipitation events, and the isotopic information provides an altative tool to investigate the atmospheric processes.