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最近研究表明,性激素、GH和Sm-C在促进人体生长发育中存在着复杂的相互作用。雌激素用于治疗发育迟缓的Turner综合征女孩,其血浆Sm-C升高抑或降低、有利还是有弊,目前仍无统一见解。本文以8名Turner征女孩为对象,探讨短期大剂量和长期小剂量雌激素对其血浆Sm-C水平和生长率的影响。 8名女孩年龄10岁8个月～14岁9个月。其中4人的核型是45,XO;其余4人为45,XO/46,XX、45,XO/46,Xr(X)、45,XO/46,Xi(X)和45,XO/46,XY。骨龄延迟,身高低于同龄女孩2～6 SD。病人入院首先作大剂量试验。1.25～
Recent studies have shown that there is a complex interaction between sex hormones, GH and Sm-C in promoting human growth and development. Estrogen for the treatment of stunted Turner syndrome girls, the plasma Sm-C increased or decreased, there are still advantages and disadvantages, there is no uniform view. In this paper, eight Turner levy girls as the object, to explore the short-term high-dose and long-term low-dose estrogen on the level of plasma Sm-C and the growth rate. Eight girls age 10 years old 8 months to 14 years and 9 months. Of which 4 were karyotype 45, XO; the remaining 4 were 45, XO / 46, XX, 45, XO / 46, Xr (X), 45, XO / 46, Xi (X) and 45, XO / 46, XY. Bone age is delayed, height is lower than girls of the same age 2 ~ 6 SD. The patient admitted to hospital for the first large dose test. 1.25 ~