本文指出妊娠第22周羊水中TSH含量能诊断先天性原发性甲状腺机能减退。并提出产前羊膜内注射Na-I-甲状腺素是治疗本病的可靠的途径。采用RIA管测定血清和羊水中TSH、fT4和T3的浓度,使用Tanner和Ncllhause图表分析身高和头围的生长参数。作者对一例孕妇在妊娠第13周时,怀疑在碘化甲状腺素合成过程中缺乏一种有机酶,故于妊娠第22周进行了羊膜穿刺术,抽 This article points out that TSH levels in amniotic fluid during the 22nd week of pregnancy can diagnose congenital primary hypothyroidism. And put forward that prenatal amniotic injection of Na-I-thyroxine is a reliable way to treat this disease. The concentrations of TSH, fT4 and T3 in serum and amniotic fluid were measured using RIA tubes and the growth parameters of height and head circumference were analyzed using the Tanner and Ncllhause charts. The author of a pregnant woman in the 13th week of pregnancy suspected of lack of an organic enzyme in the synthesis of thyroid hormone iodine, it was carried out in the 22nd week of pregnancy amniocentesis, pumping