目前采用的预防鼠疫的免疫接种程序为肌肉注射无佐剂的甲醛灭活全菌体鼠疫疫苗( KWC) ,它预防鼠疫杆菌呼吸道感染的效力尚不能肯定。已知肌注疫苗抗原通常难以诱导粘膜免疫 ,而将抗原送至呼吸道或胃肠道的诱导部位对诱导粘膜免疫是必需的。增强粘膜免疫应答的另一可能途径是通 The current immunization program for the prevention of plague is intramuscular injection of an unactivated adjuvanted formaldehyde inactivated plague vaccine (KWC) and its efficacy in preventing respiratory infection of Yersinia pestis is yet to be confirmed. It is known that intramuscular vaccine antigens are generally difficult to induce mucosal immunity, and delivery of antigens to the respiratory tract or gastrointestinal tract induction site is necessary to induce mucosal immunity. Another possible way to enhance the mucosal immune response is through