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【目的】探讨严重急性呼吸综合征 (SARS)患者外周血白细胞和T淋巴细胞亚群的变化及其临床意义。【方法】用全自动血细胞分析仪检测 4 4例SARS患者外周血白细胞计数及分类 ,用流式细胞仪检测SARS患者外周血T淋巴细胞亚群 ;并与正常对照组比较。【结果】与对照组比较 ,SARS组患者白细胞总数显著下降 ,淋巴细胞百分数和绝对数显著下降 ,粒细胞绝对数显著下降 ,粒细胞百分数显著增加 ;CD3 + 、CD4+ 和CD8+ 细胞绝对数显著下降 ,CD3 + 、CD4+ 、CD8+ 细胞百分数和CD4+ /CD8+ 比值与对照组比较无显著性差异。1年后 ,恢复期SARS患者的上述各项指标均恢复正常。【结论】SARS冠状病毒感染损伤患者中性粒细胞和细胞免疫功能 ,但这种损伤是可逆的
【Objective】 To investigate the changes of peripheral blood leukocytes and T lymphocyte subsets in patients with severe acute respiratory syndrome (SARS) and its clinical significance. 【Methods】 Peripheral white blood cell count and classification of 44 cases of SARS were detected by automatic hematology analyzer. T lymphocyte subsets in peripheral blood of patients with SARS were detected by flow cytometry. Compared with normal control group. 【Results】 Compared with the control group, the total number of white blood cells in SARS patients decreased significantly, the percentage of lymphocytes and absolute number decreased significantly, the absolute number of granulocytes decreased significantly, the percentage of granulocytes increased significantly; the absolute numbers of CD3 +, CD4 + and CD8 + The percentage of CD3 +, CD4 +, CD8 + cells and CD4 + / CD8 + ratio had no significant difference with the control group. One year later, all the above indexes of SARS patients in convalescence returned to normal. 【Conclusion】 SARS coronavirus infected neutrophils and cellular immune function, but the damage was reversible