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目的探讨埃索美拉唑联合氟哌噻吨美利曲辛治疗老年抑郁伴非糜烂性胃食管反流的疗效。方法选择2013年1月—2015年1月海军北京万寿路离职干部休养所门诊部收治的老年抑郁伴非糜烂性胃食管反流患者120例作为研究对象。采用抽签的方法将患者分为观察组与对照组,各60例。观察组患者予以埃索美拉唑联合氟哌噻吨美利曲辛治疗;对照组患者予以埃索美拉唑治疗。比较两组患者治疗前及治疗1、3个月后症状量表(Gerd Q)评分以及抑郁自评量表(SDS)评分。结果治疗前两组患者Gerd Q评分及SDS评分比较,差异无统计学意义(P>0.05);观察组治疗后1、3个月Gerd Q评分、SDS评分均低于对照组,差异有统计学意义(P<0.05)。结论埃索美拉唑联合氟哌噻吨美利曲辛治疗老年抑郁伴非糜烂性胃食管反流的疗效显著,症状缓解快,值得临床推广应用。
Objective To investigate the efficacy of esomeprazole combined with flupentixol and melitracen in the treatment of senile depression with non-erosive gastroesophageal reflux disease. Methods From January 2013 to January 2015, 120 cases of senile depression and non-erosive gastroesophageal reflux disease admitted to the Nanshan Wanshou Road Departure Cadre Recuperation Clinic were selected as research subjects. Patients were divided into observation group and control group by lottery method, 60 cases each. Patients in the observation group were treated with esomeprazole combined with flupentixol and melitracen. Patients in the control group were treated with esomeprazole. Gerd Q scores and SDS scores were compared between the two groups before treatment and 1, 3 months after treatment. Results There was no significant difference in Gerd Q score and SDS score between the two groups before treatment (P> 0.05). The Gerd Q score and SDS score of the observation group were lower than those of the control group one and three months after treatment Significance (P <0.05). Conclusion Esomeprazole combined with flupentixol and melitracen in the treatment of senile depression with non-erosive gastroesophageal reflux has significant curative effect and quick response to symptoms. It is worthy of clinical application.