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近年来,随着对潘生丁药理研究的近展,其临床应用日趋广泛,本文就近年潘生丁治疗病毒性疾病的药理及临床予以简述.1 潘生丁特性和作用机理目前潘生丁血液浓度与疗效之间的关系尚未确定,口服潘生丁在1小时内可完全吸收,2.5小时达最大血浓度.生物利用度为27～66%.该药与血浆蛋白结合率为90%.主要在肝脏与葡萄糖醛酸结合经胆汁排泄.试验证明,该药具有广谱抗病素活性,不论对RNA病毒还是DNA病毒均有效,特别对RNA病毒疗效更佳.其机理主要阻止二氧嘧啶、核苷、腺苷、尿苷及脱氧嘧啶进入细胞,从而抑制RNA的合成,而同样浓度的潘生丁对宿主细胞RNA的合成无明显影响.也有人认为其抗病毒作用与诱导干扰素活性、增加机体免疫力有关.
In recent years, with the recent exhibition on the pharmacological study of dipyridamole, its clinical application is more and more widely, this article in recent years, the treatment of viral diseases Pancandic Pharmacology and clinical summary.1 The characteristics and mechanism of dipyridamole Currently, the blood concentration of dipyridamole and the effect between The relationship has not yet been established, oral dipyridamole can be completely absorbed within 1 hour, 2.5 hours up to the maximum blood concentration. Bioavailability of 27 to 66%. The drug and plasma protein binding rate of 90%. Mainly in the liver and glucuronic acid binding Bile excretion.Experiments have shown that the drug has a broad spectrum of anti-pathogenic activity, regardless of the RNA virus or DNA virus are effective, in particular, better effect on RNA virus.The mechanism mainly to prevent dioxine, nucleoside, adenosine, uridine And deoxy pyrimidine into the cell, thereby inhibiting the synthesis of RNA, while the same concentration of dipyridamole on the synthesis of host cell RNA had no significant effect Some people think that its antiviral effect and the induction of interferon activity, increased body immunity related.