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纯光学活性物质的获得,不论是药物学上的药理研究和应用,还是生物活性物质的研究及应用,都具有重大意义。随着分离分析和测试方法的迅速发展,特别是高效液相色谱技术的不断进展,给光学活性物质的拆分带来非常有效的分离方法和制备纯品的可能。我们以自制的光学活性聚甲基丙烯酸三苯基甲酯(PTrMA)为固定相涂于YQG-ODS上,制得手性高效液相色谱填料柱,拆分了19种手性化合物,其中有8种得到较好的分离效果。 1 试剂: (+)-PTrMA~*Mn约2—3万;YQG-ODS10μm(天津化学试剂二厂制);19种手性化合物~*。
The acquisition of pure optical active substances, whether it is pharmacological pharmacological research and application, or the study and application of bioactive substances, are of great significance. With the rapid development of separation analysis and testing methods, especially the progress of HPLC, the separation of optically active substances is very effective in separation methods and the possibility of preparing pure products. We made our home-made optically active poly (triphenylmethyl) methacrylate (PTrMA) as a stationary phase on YQG-ODS to prepare a chiral HPLC column with 19 chiral compounds, of which 8 Get better separation. 1 Reagent: (+) - PTrMA ~ * Mn about 2-30000; YQG-ODS10μm (Tianjin Chemical Reagent Factory No. 2); 19 kinds of chiral compounds ~ *.