论文部分内容阅读
调节母体的免疫系统,使胎儿作为同种异体移植物存活的机理尚不清楚。胚胎植入子宫内膜时透明带或粘蛋白外衣的消失并未能使胚胎更易被排除或变性。关于母体这种免疫耐受现象已有多种解释。已发现妊娠9天家兔的囊胚腔液较母体自身血有更高的免疫抑制活性。本文研究了家兔妊娠期和假孕时囊胚腔液和血清免疫抑制活性的变化。将动情期定为实验0天,家兔交配后注射人绒毛膜促性腺激素(hCG)诱导妊娠;给未交配的家兔注射hCG以形成假孕。于妊娠8至12、13、
The mechanism by which the mother’s immune system is regulated so that the fetus survives as an allograft remains unclear. The disappearance of zona pellucida or mucin coat when the embryo is implanted in the endometrium does not make the embryo easier to exclude or degenerate. Various explanations have been given regarding this phenomenon of immune tolerance of the mother. It has been found that the rabbit blastocyst fluid has a higher immunosuppressive activity than the mother’s own blood at 9 days of gestation. In this paper, we studied the changes of immunosuppressive activity of blastocyst fluid and serum in rabbits during pregnancy and pseudopregnancy. The estrus period was defined as experiment 0 days. Rabbits were injected with human chorionic gonadotropin (hCG) to induce pregnancy. Unpaired rabbits were injected with hCG to form pseudopregnancy. In pregnancy 8 to 12, 13,