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目的观察莫西沙星治疗老年耐多药肺结核患者的疗效。方法 76例耐多药的老年肺结核患者按照随机数字表法分为两组,观察组38例,对照组38例,观察组患者在常规化疗的基础上加用莫西沙星,对照组在常规化疗的基础上加用左氧氟沙星。分析治疗12个月后两组患者的X线和痰菌转阴的情况。结果观察组病灶好转率为94.7%,对照组好转率为92.1%,两组比较差异无统计学意义(P>0.05)。两组治疗后患者空洞变化差异无统计学意义(P>0.05)。观察组治疗12月后痰菌转阴率为94.7%,对照组痰菌转阴率为79%,两组比较差异有统计学意义(P<0.01)。观察组总有效率为97.4%,对照组总有效率为84.2%,两组比较差异有统计学意义(P<0.01)。结论加用莫西沙星的抗结核治疗可以明显提高老年耐多药肺结核的痰菌转阴率,提高临床疗效。
Objective To observe the efficacy of moxifloxacin in elderly patients with multidrug-resistant pulmonary tuberculosis. Methods A total of 76 elderly patients with MDR-TB were divided into two groups according to random number table: 38 cases in the observation group and 38 cases in the control group. Moxifloxacin was added to the observation group on the basis of conventional chemotherapy. In the control group, Based on the addition of levofloxacin. Analysis of 12 months after treatment of the two groups of patients with X-ray and sputum negative situation. Results The rate of improvement in the observation group was 94.7%, and the improvement rate in the control group was 92.1%. There was no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups in patients after treatment of cavity changes (P> 0.05). After 12 months of treatment, the sputum negative conversion rate was 94.7% in the observation group and 79% in the control group. The difference between the two groups was statistically significant (P <0.01). The total effective rate was 97.4% in the observation group and 84.2% in the control group, with significant difference between the two groups (P <0.01). Conclusion The anti-TB treatment with moxifloxacin can significantly improve the rate of sputum negative conversion rate in elderly multi-drug resistant pulmonary tuberculosis and improve the clinical efficacy.