报道原发性高血压非卒中病人,卒中病人和正常对照的HLA-A、B抗原频率调查。HLA-B12抗原频率,在原发性高血压总病人组中显著增高,卒中病人增高尤为显著,非卒中病人虽也增高,但末达到显著水平。HLA-B13抗原频率在非卒中组和对照组、卒中组和对照组之间者5无显著差异,但卒中组比非卒中组显著增高,提示B13与原发性高血压易感无关,但原发性高血压病人中B13携带者的卒中风险显著增高。B13可作为检出卒中高发病人的一种遗传标志。 The frequency of HLA-A and B antigens in non-stroke patients with essential hypertension, stroke patients and normal controls was investigated. HLA-B12 antigen frequency in patients with essential hypertension was significantly higher in the group, stroke patients increased particularly significantly, although non-stroke patients also increased, but did not reach a significant level. HLA-B13 antigen frequency in non-stroke group and control group, stroke group and control group 5 no significant difference, but the stroke group was significantly higher than non-stroke group, suggesting that B13 and essential hypertension has nothing to do, but the original The risk of stroke in B13 carriers was significantly higher in patients with essential hypertension. B13 can be used as a genetic marker to detect the high incidence of stroke.