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大白鼠注射~(125)I标记的纤维蛋白原后,再注射凝血酶,造成弥散性血管内凝血。放射自显影检查发现,同位素标记的微血栓主要位于肾小球毛细血管,直小血管之中。肺泡的毛细血管也可发现这些微血栓。肝脏和脾脏的网状内皮细胞吞噬了大量的标记物质,这些吞噬细胞定位在肝门区,而在脾脏则位于马氏小体周围。此外,在肾小管的上皮细胞内也发现有同位素,这些物质可能是通过肾小球过滤而被肾小管重吸收的标记物质。用自显影术,常规染色和纤维蛋白的特殊染色互相比较,肺的微血栓在常规和特殊染色中不能被发现,用自显影术则很易检出同位素标记的微血栓。
Rats injected ~ (125) I labeled fibrinogen, and then injected thrombin, resulting in disseminated intravascular coagulation. Autoradiography examination revealed that isotope-labeled microthrombi mainly located in the glomerular capillaries, straight blood vessels. Alveolar capillaries can also be found in these microthrombi. The reticuloendothelial cells of the liver and spleen engulf large numbers of labeling substances, which are located in the hilar region, while in the spleen, they are located around the Martensite. In addition, isotopes are also found in the epithelial cells of the renal tubules, and these substances may be markers that are reabsorbed by renal tubules via glomerular filtration. With autoradiography, routine staining and special staining of fibrin, lung microthrombi can not be found in routine and special staining, and isotope labeled microthrombi can be easily detected with autoradiography.