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目的 :观察奥美拉唑联合普瑞博思治疗返流性食管炎的近期疗效。方法 :对 5 2例确诊的返流性食管炎患者给予奥美拉唑 2 0mg ,1次 /d ,早餐前服用 ;普瑞博思 10mg/次 ,3次 /d ,餐前服用 ,共 4周。结果 :胃镜总积分治疗前 1.40± 1.0 5分 ,治疗后 0 .87± 0 .93分 ,前后差异非常显著 (P <0 .0 1) ;症状消失率 1周为 44.2 3 % (2 3/5 2 ) ,2周为 78.85 % (41/5 2 ) ,3周84.6 2 % (44 /5 2 ) ,4周为 90 .38% (47/5 2 ) ,4周内镜下痊愈率为 5 0 .0 0 % (2 6 /5 2 )。初始服药时 ,出现腹泻 1例 ,腹痛 1例 ,发生率 3 .85 %。结论 :4周疗法症状消失快 ,不良反应少 ,依顺性好 ,是治疗返流性食管炎较理想的方法。但内镜下痊愈率不高 ,对部分患者需延长疗程。
Objective: To observe the short-term curative effect of omeprazole and pregloss in the treatment of reflux esophagitis. Methods: 52 patients with reflux esophagitis were given omeprazole 20mg once a day for breakfast before taking Pregabalin 10mg / time 3 times a day for 4 weeks . Results: The total score of gastroscopy was 1.40 ± 1.05 before treatment and 0.87 ± 0.93 after treatment, with significant difference before and after treatment (P <0.01). The rate of disappearance of symptoms was 44.2 3% (2 3 / 5 weeks), 78.85% (41/5 2) in 2 weeks, 84.62% (44/5 2) in 3 weeks and 90.38% (47/5 2) in 4 weeks. The recovery rate after 4 weeks was 5 0 .0 0% (2 6/5 2). Initial medication, diarrhea in 1 case, abdominal pain in 1 case, the incidence of 3.85%. Conclusion: The symptoms of 4 weeks disappeared quickly, with fewer adverse reactions and good compliance. It is an ideal method for the treatment of reflux esophagitis. However, endoscopic recovery rate is not high, some patients need to extend the course of treatment.