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超抗原是一些细菌的外毒素和病毒编码的蛋白质分子 ,它的一端与抗原提呈细胞上的主要组织相容性复合体Ⅱ类分子相结合 ,另一端识别TCR的Vβ片段 ,不需加工处理 ,能激活比普通抗原更多的T细胞。超抗原抗肿瘤的机制包括T细胞的直接杀伤作用和细胞因子的作用。基于超抗原的肿瘤基因治疗模式有单用单克隆抗体片段导向的超抗原抗肿瘤、超抗原基因转染抗肿瘤、超抗原基因联合其他基因抗肿瘤和膜锚定超抗原瘤苗抗肿瘤。基于超抗原的肿瘤基因治疗是一种新的肿瘤生物治疗模式 ,将为肿瘤的治疗带来新的希望
Superantigens are exotoxins of some bacteria and virus-encoded protein molecules, one end of which binds to the major histocompatibility complex class II molecule on antigen presenting cells and the other end recognizes the V [beta] fragment of TCR without the need for processing , Can activate more than normal antigen T cells. Anti-tumor mechanisms of superantigens include the direct killing of T cells and the effects of cytokines. Based on superantigen-based tumor gene therapy models, monoclonal antibody fragment-directed superantigen anti-tumor and superantigen gene transfection were used to antitumor and superantigen genes combined with other gene anti-tumor and membrane-anchored superantigens. Tumor gene therapy based on superantigen is a new tumor biotherapy model that will bring new hope for the treatment of cancer