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对１２例慢性肺心病急性发作期患者，均以静脉注射负荷剂量（５０μｇ·ｋｇ￣（－１））继以静滴（每分钟０．５μｇ·ｋｇ￣（－１））维持４ｈ给予米利酮后进行药动学分析。其血药浓度采用ＨＰＬＣ测定，线性范围１０～３２０ｎｇ·ｍｌ￣（－１），回收率９８．８％～１０６．７％，日内、日间ＲＳＤ分别为３．９５％～４．７４％，４．２４％～６．３７％，最低检出限为４ｎｇ·ｍｌ￣（－１）。以Ｔｕｒｂｏ一ＢＡＳＩＣ语言编制程序在３８６／３３兼容机上进行数据处理，求出药动学参数。药时曲线经计算机自动拟合后，９例患者符合二室模型，求得的ＡＵＣ为６３３．６±１７７．７ｎｇ·ｍ１￣（－１）·ｈ，清除半衰期为１．５９±０．７２ｈ，血浆清除率为１５．８８±２．７６Ｌ·ｈ￣（－１），药物分布容积为１４．３３±５．３４Ｌ．另外３例患者符合一室模型，其ＡＵＣ为８７４．４±２７５．８ｎｇ·ｍｌ￣（－１）·ｈ，清除半衰期为１．５４±０．５４ｈ，血浆清除率为１３．０６±６．６７Ｌ·ｈ￣（－１），分布容积为２５．９±４．０９Ｌ。此外，米利酮的降低肺动脉压的作用与血药浓度呈依赖性变化。
In 12 patients with acute exacerbation of chronic pulmonary heart disease, all patients were given intravenous injection of dose (50μg · kg ~ (-1)) followed by intravenous drip (0.5μg · kg ~ (-1) per minute) After the pharmacokinetic analysis. The plasma concentration was determined by HPLC. The linear range was 10 ~ 320ng · ml ~ (-1) and the recovery was 98.8% ~ 106.7%. The intra-day and inter-day RSD were 3.95% ~ 4.74% 4.24% ~ 6.37%, the lowest detection limit of 4ng · ml ~ (-1). To Turbo a BASIC language programming procedures in the 386/33 compatible data processing, pharmacokinetic parameters. After the curve of the drug was automatically fitted by computer, 9 patients met the two-compartment model, and the AUC was 633.6 ± 177.7ng · m1¯ (-1) · h and the elimination half-life was 1.59 ± 0.72h , The plasma clearance rate was 15.88 ± 2.76L · h ~ (-1), the drug distribution volume was 14.33 ± 5.34L. The other 3 patients were in accordance with the one-compartment model. The AUC was 874.4 ± 275.8 ng · ml -1, the half-life was 1.54 ± 0.54 h, and the plasma clearance rate was 13.06 ± 6. 67L · h ~ (-1), the volume of distribution is 25.9 ± 4.09L. In addition, the effect of milrinone on lowering pulmonary arterial pressure changes in a concentration dependent manner.