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本文观察了缓激肽、钾离子、组织胺等诱致麻醉兔隐神经传入纤维放电的作用及金丝桃甙对上述致痛因子作用的影响。经股动脉注射缓激肽0.3μg/kg、1％KCl 0.25ml/kg、组织胺150μg/kg,均能显著诱发隐神经传入放电(比基础放电分别提高3.5、4.3、3.6倍,均为p<0.01);同一途径给予金丝桃甙10mg/kg,对缓激肽、组织胺作用的抑制率分别高达75.6％和90.8％;金丝桃甙5mg/kg对KCl作用的抑制率高达73.3％。金丝桃甙在给药后5分忡内即迅速起效并达作用高峰,维付45分钟以上。同法给予吗啡2mg/kg不能对抗缓激肽的作用。上述结果表明,金丝桃甙具有外周镇痛作用,它可能通过影响致痛因子对痛觉传入神经的激活过程发挥作用。
In this paper, the effects of bradykinin, potassium, histamine and other drugs on the afferent fibers induced by anesthetized rabbit saphenous nerve and the effect of hyperin on the above-mentioned pain-inducing factors were observed. By injecting bradykinin 0.3μg / kg, 1% KCl 0.25ml / kg and histamine 150μg / kg into the femoral artery, all can significantly induce the afferent nerve discharge (3.5, 4.3, 3.6 times higher than the basic discharge, (P <0.01). The same way was given hypericin 10mg / kg, the inhibitory rates of bradykinin and histamine were as high as 75.6% and 90.8%, respectively. The inhibition rate of hyperin to KCl was as high as 73.3 %. Hyperin in 5 minutes after administration within the rapid onset and up to the peak effect, pay for more than 45 minutes. The same law given morphine 2mg / kg can not fight bradykinin role. The above results indicate that hyperin has a peripheral analgesic effect that may play a role in the activation of pain-inducing nerves by affecting the pain-inducing factor.