前列腺素 E(PGE)能被胃肠粘膜合成,也能保护胃肠粘膜,在不同情况下,PGE 又导致胃肠粘膜损伤。Gould(1975)研究了PGE 与溃疡性结肠炎的关系,发现溃疡性结肠炎病人大便中 PGS 增高,以后 Harris 检测了溃疡性结肠炎病人直肠粘膜内 PGE 合成酶的活力,以及血浆内 PG 类,新近还有些研究,探索 PGE 升高引起的病理生理、症候以及激素和柳氮磺胺吡啶阻抑 PGE 合 Prostaglandin E (PGE) can be synthesized by the gastrointestinal mucosa, but also protect the gastrointestinal mucosa, PGE in turn leads to gastrointestinal mucosal injury. Gould (1975) studied the relationship between PGE and ulcerative colitis and found that patients with ulcerative colitis increased PGS in the stool. After that, Harris examined the activity of PGE synthetase in the rectal mucosa of patients with ulcerative colitis, Recently there are some studies to explore the pathophysiology caused by elevated PGE, symptoms and hormone and sulfasalazine inhibition of PGE