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目的:观察复方丹参滴丸联用氟伐他汀对颈动脉粥样斑块的干预作用。方法:选择116例门诊颈动脉粥样斑块的患者随机分为三组:复方丹参滴丸组(39例),在常规治疗基础上加服复方丹参滴丸10粒,tid;氟伐他汀组(39例),在常规治疗基础上加服氟伐他汀40 mg,每晚1次;联合治疗组(38例),在常规治疗的基础上,应用复方丹参滴丸10粒,tid,氟伐他汀40 mg,每晚1次,均连用6个月。所有患者均于服药前和服药后6个月行颈动脉超声检查,观察各组患者用药前后颈动脉粥样斑块的变化,并进行比较。结果:三组患者用药前后自身对照,颈动脉粥样斑块明显减轻[(2.32±1.47)vs(1.71±1.10),(2.41±0.38)vs(2.05±0.36),(2.35±0.51)vs(1.33±0.34),P<0.05],用药前后复方丹参滴丸组与氟伐他汀组间无明显差异[(2.32±1.47)vs(2.41±0.38),(1.71±1.10)vs(2.05±0.36),P>0.05],但用药后联合治疗组均较复方丹参滴丸组和氟伐他汀组明显减轻[(1.33±0.34)vs(1.71±1.10),(1.33±0.34)vs(2.05±0.36),P<0.05],各组均未见明显的不良反应。结论:复方丹参滴丸和氟伐他汀对颈动脉粥样斑块均有明显的抑制作用,两药联用效果更佳,且无明显的不良反应。
Objective: To observe the effect of Fufang Danshen Diwan combined with fluvastatin on carotid artery plaque. Methods: A total of 116 outpatients with carotid artery atherosclerotic plaque were randomly divided into three groups: Compound Danshen Dripping Pill (39 cases). On the basis of conventional treatment, 10 cases of compound Danshen Dripping Pills (39 cases), on the basis of routine treatment plus fluvastatin 40 mg, 1 night; combination therapy group (38 cases), on the basis of routine treatment, the application of compound Danshen dripping pills 10, tid, Statin 40 mg, 1 night, were used in conjunction for 6 months. All patients underwent carotid ultrasonography before taking the medicine and 6 months after taking the medicine. The changes of carotid artery atherosclerotic plaques in each group were observed and compared. Results: The carotid atherosclerotic plaques in the three groups were significantly reduced before and after treatment [(2.32 ± 1.47 vs 1.71 ± 1.10, 2.41 ± 0.38 vs 2.05 ± 0.36 vs 2.35 ± 0.51 vs 1.33 ± 0.34, P <0.05]. There was no significant difference between fluvastatin group and fluvastatin group before and after treatment [(2.32 ± 1.47 vs 2.41 ± 0.38, 1.71 ± 1.10 vs 2.05 ± 0.36, , P> 0.05]. However, the combined treatment group was significantly less than the compound Danshen dripping and fluvastatin groups (1.33 ± 0.34 vs 1.71 ± 1.10, 1.33 ± 0.34 vs 2.05 ± 0.36, , P <0.05], no obvious adverse reactions were found in all groups. Conclusion: Both compound Danshen dripping pills and fluvastatin have obvious inhibitory effect on carotid artery plaque, and the two drugs are better combined with no obvious adverse reactions.