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以胰岛素抵抗为特征的代谢综合征及2型糖尿病患者倾向于更早期发生弥漫性动脉粥样硬化,甚至出现于高血糖之前,动脉粥样硬化是糖尿病死亡的首要原因.除了传统危险因素外,近年发现一直被认为无生物活性的C肽可能参与了动脉粥样硬化的关键发展步骤,其参与了炎症反应、促进单核巨噬细胞迁移趋化及向泡沫细胞转化、促进血管平滑肌细胞的增殖,几项队列研究提示血清C肽水平升高与全因死亡、心血管疾病、恶性肿瘤死亡相关.文章就C肽的生物学作用从基础研究到临床研究进展做一综述.“,”The patients with metabolic syndrome or type 2 diabetes mellitus are characterized by insulin resistance and have more risks to develop extensive atherosclerosis,even it occurs before hyperglycemia.Atherosclerosis is the leadng cause of death in diabetic population.Thus it is important to explore the mechanisms of atherosclerosis.Besides the traditional risk factors,C-peptide which is considered no biological activity may play role in atherogenesis.It involves inflammation of artery and results in monocyte/macrophage accumulation as well as smooth muscle cell proliferation.Several cohort studies suggest that increased C-peptide levels relate to all-cause death,cardiovascular disease and cancer mortality.This review focuses on the new biological functions of C-peptide based on in vitro,vivo research and clinical studies.