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Toll样受体(TLRs)是机体固有免疫系统的受体之一,外界微生物可与TLRs结合并激活固有免疫、炎性反应,并进一步启动获得性免疫反应。近年研究发现一些内源性配体也可与TLRs结合,激活炎性反应。近年来,糖尿病的发生率逐年递增,由此导致的糖尿病肾病(DN)成为导致终末期肾脏疾病最主要的原因之一。目前对于TLRs与DN关系的研究较少,仅限于TLR2和TLR4。研究表明,TLR2和TLR4可通过介导代谢性炎性反应而调节糖尿病及DN的发生、发展过程。
Toll-like receptors (TLRs) are one of the receptors of the body’s innate immune system. The outside world microorganisms can bind to TLRs and activate innate immunity and inflammatory responses and further activate adaptive immune responses. In recent years, studies have found that some endogenous ligands can also bind to TLRs and activate the inflammatory response. In recent years, the incidence of diabetes increased year by year, resulting in diabetic nephropathy (DN) has become the leading cause of end-stage renal disease, one of the reasons. Currently, there are few studies on the relationship between TLRs and DN, only TLR2 and TLR4. Studies have shown that TLR2 and TLR4 can regulate the occurrence and development of diabetes mellitus and DN by mediating the metabolic inflammatory response.