论文部分内容阅读
目的探讨美托洛尔联合尼莫地平预防偏头痛的临床效果。方法将84例偏头痛患者随机分为治疗组与对照组,每组42例。治疗组予琥珀酸美托洛尔和尼莫地平治疗,对照组予美托洛尔治疗。要求患者学习头痛日记记录方法,内容包括偏头痛发作频率、头痛持续时间、头痛程度(用0~10分代表不同程度的疼痛,0分为无痛,10分为剧痛)。并比较两组治疗后3、6、9个月疗效。结果治疗组治疗后9个月总有效率为88.09%,对照组为80.95%,差异有统计学意义(P<0.05)。治疗组治疗后3个月的头痛发作次数、持续时间及发作程度(3、6、9个月)评分与对照组治疗后比较,差异有统计学意义(P均<0.05)。两组不良反应发生率比较,P<0.05差异有统计学意义。结论美托洛尔联合尼莫地平可有效预防偏头痛发作程度,减轻不良反应。
Objective To investigate the clinical effect of metoprolol combined with nimodipine in the prevention of migraine. Methods Eighty-four migraine patients were randomly divided into treatment group and control group, with 42 cases in each group. The treatment group metoprolol succinate and nimodipine treatment, the control group metoprolol treatment. Patients were asked to learn how to record headache diaries, including the frequency of migraine attacks, the duration of their headaches, and their headache (0 to 10 for varying degrees of pain, 0 for painless, and 10 for severe pain). The efficacy of 3, 6, and 9 months after treatment was compared between the two groups. Results In the treatment group, the total effective rate was 88.09% at 9 months and 80.95% in the control group, the difference was statistically significant (P <0.05). The number of headache episodes, duration and extent of attack (3, 6 and 9 months) in the treatment group at 3 months after treatment were significantly different from those in the control group after treatment (all P <0.05). Adverse reactions between the two groups, P <0.05 difference was statistically significant. Conclusion Metoprolol combined with nimodipine can effectively prevent migraine attacks and reduce adverse reactions.