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肽抗生素LL 37是一种内源性抗生素 ,为人体内发现的cathelicidin家族的惟一成员。其前体hCAP18经蛋白酶加工去除N端高度保守的cathelin后 ,才能形成具有生物活性、相对分子质量约为 5 0 0 0的LL 37。LL 37对革兰阴性和阳性菌均有广谱抗菌作用 ,其抗菌活性依赖于α 螺旋结构的形成。血浆中的apoA Ⅰ可结合LL 37并抑制其细胞毒性作用 ,从而使机体免受LL 37的损伤。除抗微生物活性外 ,LL 37还具有结合与中和内毒素、趋化及促进血管生成等作用。
Peptide antibiotic LL 37 is an endogenous antibiotic and is the only member of the cathelicidin family found in the human body. After its precursor hCAP18 was proteolytically processed to remove the highly conserved cathelin at the N-terminus, LL37 with biological activity and relative molecular mass of about 500 was formed. LL 37 has broad-spectrum antibacterial activity against Gram-negative and -positive bacteria, and its antibacterial activity depends on the formation of α-helical structure. ApoAI in plasma binds to LL37 and inhibits its cytotoxic effects, thereby protecting the body from LL37 injury. In addition to anti-microbial activity, LL 37 also has the role of binding and neutralization of endotoxin, chemotaxis and promote angiogenesis.