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本文作者以62例胰岛素瘤(良性61例,恶性1例)切除的标本为材料,用10种肽类激素抗血清进行免疫过氧化物酶染色,以观察肿瘤中所含的内分泌细胞成分,发现多数肿瘤含有免疫活性多肽,但主要为胰腺分泌的肽类激素。其中39例(占62.9％)含两种以上内分泌细胞,包括A.B.D.PP及少量G细胞,无一例含M.S.D_1(VIP)K(GIP)或NT细胞。虽有62.9％的肿瘤含多种内分泌细胞,但全组61例临床表现为典型的低血糖胰岛素瘤,仅1例同时有胰岛素瘤和胃泌素瘤的症状,说明约50％以上的胰内分泌肿瘤虽表现为多激素性,但临床常只出现一种激素所引起的症状。
The authors of this paper used 62 specimens of insulinoma (61 cases with benign and 1 malignancy) as materials, and used 10 peptide hormone antiserum to perform immunoperoxidase staining to observe the endocrine cell components contained in the tumor. Most tumors contain immunologically active peptides, but they are mainly peptide hormones secreted by the pancreas. Thirty-nine of them (62.9%) contained more than two kinds of endocrine cells, including A.B.D.PP and a small amount of G cells, and none contained M.S.D_1(VIP)K(GIP) or NT cells. Although 62.9% of tumors contained a variety of endocrine cells, 61 cases of the whole group showed typical hypoglycemic insulinomas, and only 1 case had both insulinoma and gastrinoma symptoms, indicating that about 50% of pancreatic endocrine secretion. Although the tumor appears to be polyhormonal, clinically there is often only one hormone-induced symptom.