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I型代谢型谷氨酸受体(metabotropic glutamate receptors,mGluRs)在中枢神经系统(central nervou sysytem,CNS)中参与了很多重要的生理功能,如调控兴奋性神经信号传导,参与痛觉、痒、以及药物成瘾的产生,并且与癫痫、脑缺血、帕金森病等神经系统疾病有密切联系~[1]。然而,以I型mGluRs为药物靶点的药物并不广泛,主要是其作用的机制并不清楚。而研究mGluR1/5在神经系统中发挥功能的作用机制,
The metabotropic glutamate receptors (mGluRs) are involved in many important physiological functions in the central nervous system (CNS), such as regulating excitatory nerve signal transduction, participating in pain sensation, itching, and Drug addiction, and with epilepsy, cerebral ischemia, Parkinson’s disease and other nervous system diseases are closely linked to [1]. However, drugs targeting type I mGluRs are not widely available, and the mechanism underlying their effects is not clear. While studying the mechanism of mGluR1 / 5 functioning in the nervous system,