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目的 检测桦木尘水提取液和有机提取液的致癌性。方法 采用小鼠肺肿瘤短期诱发实验的一阶段和两阶段模型。结果 桦木尘水提取液和有机提取液在小鼠肺肿瘤一阶段短期诱发实验中未引起小鼠肺肿瘤的明显增加 ;小鼠肺肿瘤短期诱发两阶段实验中 ,桦木尘水提取液的 1、2、4g/kg三个剂量组诱发的平均肿瘤数和肺肿瘤发生率分别为 0 .0 4、4.0 8%,0 .15、8.33%和 0 .2 4、14.30 %,随着剂量的增加而有所提高 ,经回归曲线拟合方差分析 ,存在明显的剂量 -效应关系 (P <0 .0 5 ) ,其中 ,4g/kg剂量组小鼠平均肿瘤数和肿瘤发生率与对照组、1g/kg组和相同剂量的一阶段组相比 ,差异有显著性 (P <0 .0 5 ) ;桦木尘有机提取液亦引起了肺肿瘤发生率和平均肿瘤数的增加 ,但各组之间差异无显著性 (P >0 .0 5 )。结论 桦木尘提取液可能为一启动剂 ,桦木尘水提取液的致癌性强于有机提取液。
Objective To detect the carcinogenicity of birch dust extract and organic extract. Methods One-stage and two-stage models of short-term induction of lung tumor in mice were used. Results The birch dust extracts and organic extracts did not cause significant increase of lung tumors in mice in one-stage short-term induction of lung cancer. In two-stage experiments, The average number of tumors and the incidence of lung tumors induced by 2,4g / kg three dose groups were 0.0,4.0 8%, 0,15,8.33% and 0,2 4,14.30% respectively. With the increase of dose (P <0.05). There was a significant dose-response relationship between the two groups (P <0.05). The average number of tumors and the incidence of tumors in the 4g / kg dose group were significantly lower than those in the control group, 1g / kg group compared with the same dose of the first-phase group, the difference was significant (P <0. 05); birch dust organic extract also caused an increase in the incidence of lung cancer and the average number of tumors, but between the groups There was no significant difference (P> 0.05). Conclusion birch dust extract may be a promoter, birch dust extract carcinogenicity stronger than the organic extract.