慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是呼吸系统常见病,多发生于老年人,而骨质疏松症亦为老年常见病,目前较多的研究表明,COPD与骨质疏松症的产生关系密切,且发病率明显高于同龄健康人,其发病机制尚未明确。随着患者病情进展,骨质疏松症发病率可达30%～60%。约75%Ⅳ期COPD患者出现骨量减少。COPD患者存在诸多导致骨代谢紊乱的因素,其中包括吸烟、应用糖皮质激素、慢性缺氧、营养不良、户外活动减少、代谢紊乱等。现综述 Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, occurs in the elderly, and osteoporosis is also a common disease of the elderly, the current more studies have shown that COPD and osteoporosis Have a close relationship, and the incidence was significantly higher than healthy people of the same age, the pathogenesis is not yet clear. With the progress of patients, the incidence of osteoporosis up to 30% to 60%. About 75% of patients with stage Ⅳ COPD have osteopenia. COPD patients have many factors that lead to disorders of bone metabolism, including smoking, glucocorticoids, chronic hypoxia, malnutrition, decreased outdoor activities, metabolic disorders. Now review