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目的 探讨抗癌药不同给药途径在肿瘤组织内药物浓度的聚积性。方法 对 2 0例切除的进展期胃癌进行术前氟尿嘧啶 (5 Fu)腹腔、静脉化疗的药代动力学研究。术前 5 Fu72 0mg m2 加生理盐水 75 0ml分别腹腔、静脉给药 ,注射后 6 0～ 80min取腹腔液、门静脉及外周血 ,2 10～ 2 40min取癌组织、腹膜及阴性淋巴结 ,应用高效液相色谱法 (HPLC)测定 5 Fu浓度。结果 腹腔给药各组组织内聚积的药物浓度较高 ,其中腹膜浓度最高 ,超出静脉给药组近 4倍。腹腔液、门静脉、外周血分别超出静脉给药组的 15 ,3 8,2倍。结论 大剂量 5 Fu术前腹腔化疗能预防和治疗胃癌术后腹腔复发和肝转移 ,并较传统的静脉化疗为优
Objective To investigate the accumulation of drug concentration in tumor tissue of different anticancer drugs. Methods The pharmacokinetics of preoperative fluorouracil (5 Fu) intraperitoneal and intravenous chemotherapy was performed in 20 cases of advanced gastric cancer. Preoperative 5 Fu72 0mg m2 plus saline 75 0ml were administered intraperitoneally and intravenously. Peritoneal fluid, portal vein and peripheral blood were taken at 60-80 min after injection. Cancer tissue, peritoneum and negative lymph nodes were taken from 10 to 24 minutes. The 5 Fu concentration was determined by phase chromatography (HPLC). Results The intraperitoneal administration of the drug accumulated in the tissues of each group was higher, with the highest peritoneal concentration, which was nearly 4 times higher than that of the intravenous administration group. Peritoneal fluid, portal vein, and peripheral blood exceeded the intravenous administration group 15, 3,2 times. Conclusion High-dose 5 Fu preoperative intraperitoneal chemotherapy can prevent and treat intra-abdominal recurrence and liver metastasis after gastric cancer surgery, and is superior to traditional intravenous chemotherapy.