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在过去１０年间，５－氟尿嘧啶（５－Ｆｕ）一直是胃肠道肿瘤治疗的主要选择，然而它的疗效不尽人意。目前已证实甲酰四氢叶酸钙（Ｌｅｕｃｏｖｏｒｉｎ，ＬＶ）通过延长对胸腺嘧啶合成酶的阻滞来增强５－Ｆｕ的细胞毒性作用。５－Ｆｕ＋ ＬＶ的联合方案已成为目前临床上最常用
In the past 10 years, 5-fluorouracil (5-Fu) has been the main choice for the treatment of gastrointestinal cancer, however, its efficacy is not satisfactory. It has been demonstrated that Leucovorin (LV) enhances the cytotoxic effects of 5-Fu by prolonging the blockade of thymidine synthase. 5-Fu + LV joint program has become the most clinically used