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子宫内膜癌(Endometrial Carcinoma,EC)是妇科常见恶性肿瘤,随着雌激素应用、肥胖增多及饮食改变,发病率逐年增高,尽管诊疗水平已显著提高,患者五年生存率超过80%[1],但明确子宫内膜癌发生和转移的信号通路机制,对彻底有效地治疗子宫内膜癌意义重大。本文将常见的信号通路与子宫内膜癌发病机制间的关系做一综述。
Endometrial cancer (EC) is a common malignant tumor in gynecology. With estrogen application, obesity increased and diet changed, the incidence increased year by year. Although the level of diagnosis and treatment has been significantly improved, the five-year survival rate of patients is over 80% [1 However, it is of great significance to thoroughly and effectively treat the endometrial cancer by clarifying the signaling pathway of the occurrence and metastasis of endometrial cancer. This article reviews the relationship between the common signal pathways and the pathogenesis of endometrial cancer.