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机体免疫反应有助于控制慢性结核分枝杆菌感染,但不能将其清除。细胞免疫在清除结核分枝杆菌感染中起着重要作用,包括CD4+Th细胞和CD8+T细胞以及高水平Th1类细胞因子。近年研究表明,在慢性病原体感染中存在具有调节功能的CD4+CD25+T细胞亚群,剔除这群细胞能够增加机体的免疫反应,它们在结核分枝杆菌慢性感染的发病机制中也起着重要作用。此文就目前有关调节性T细胞的分化和功能,及其在结核分枝杆菌感染中的意义和作用机制等研究进展作一综述。
The body’s immune response helps control chronic M. tuberculosis infection, but it can not be cleared. Cellular immunity plays an important role in clearance of M. tuberculosis infection, including CD4 + Th cells and CD8 + T cells, and high levels of Th1-type cytokines. In recent years, studies have shown that there is a regulatory subpopulation of CD4 + CD25 + T cells in chronic pathogen infection. Excluding these cells can increase the body’s immune response, which also plays an important role in the pathogenesis of chronic Mycobacterium tuberculosis infection effect. This review summarizes the current research progress on regulatory T cell differentiation and function, its significance and mechanism of action in Mycobacterium tuberculosis infection.