涎腺组织发生的腺泡细胞癌主要位于腮腺,其次为口内小涎腺、颌下腺、舌下腺以及鼻腔鼻窦、喉、肺的涎腺组织。井上(1984)复习英、日文资料,共得来自小涎腺的腺泡细胞癌80例,大多位于腭、颊粘膜及唇部。鼻腔鼻窦腺泡细胞癌美国文献迄今只有3例,作者报告为第4例。该例光镜显示成片、成簇或单个大细胞,基质水肿,血管丰富。细胞长径30～100μm,胞浆嗜酸性,具纤细颗粒或接近透明。胞浆透明者表现为空泡化的后期,类似泡沫样细胞、巨型蛛-网状细胞及神经节样细胞的中间阶段。偶尔细胞内含脂褐素。细胞核形一致,视胞浆空泡化程度核可位于中央或周边。光镜下难与横纹肌肉瘤、副神经节瘤、具有气球样细胞的恶性黑素瘤、牙龈肉瘤、神经节瘤区分。组化反应证实黑素和线粒体均为阴性。免疫组织化学PAP法,S-100蛋白、5-羟色胺、高血糖素、肌球蛋白及降钙素均为阴性而淀粉酶阳性。电镜见细胞外形一致、较大,细胞膜紧密接触,散在小的 Acinar cell carcinoma of the parotid gland is mainly located in the parotid gland, followed by salivary gland tissue in the mouth, submandibular gland, sublingual gland, nasal sinus, larynx and lung. Inoue (1984) reviewed the English and Japanese data and obtained a total of 80 cases of acinar cell carcinoma from the small parotid gland, most of which were located in the temporal, buccal and lip areas. The nasal cavity and sinus acinus cell carcinoma has so far only 3 cases in the United States, and the author reported it as the fourth case. In this example, the light microscopy showed lamellae, clusters, or single large cells with matrix edema and rich blood vessels. Cell length 30 ~ 100μm, eosinophilic cytoplasm, with fine particles or nearly transparent. Cytoplasmic transparency manifests itself in the late phase of vacuolation and resembles the intermediate stages of foam-like cells, giant spider-reticular cells, and ganglion-like cells. Occasionally, cells contain lipofuscin. The cell nucleus is uniform and the degree of cytoplasm vacuolation can be located centrally or peripherally. Under light microscope, it is difficult to distinguish from rhabdomyosarcoma, paraganglioma, malignant melanoma with balloon-like cells, gingival sarcoma, and ganglionoma. The histological reaction confirmed that both melanin and mitochondria were negative. Immunohistochemical PAP method, S-100 protein, serotonin, glucagon, myosin, and calcitonin were all negative and amylase positive. Electron microscopy shows that the cells have the same shape and larger size, and the cell membranes are in close contact with each other, scattered in small