论文部分内容阅读
Oxmetidine(S K&F 92994)是一种新的特异性组织胺H_2-受体拮抗剂,它对健康的自愿受试者和消化性溃疡患者均具有抑制基础胃酸分泌和激发后的胃酸分泌作用。健康人在Impromidine刺激后,随之静脉注射Oxmetidine,在毫克对等基础上,Oxmetidine的效力为甲氰咪胍的4倍。口服时,两种制剂效力相似,因Oxmetidine的口服生物可利用率约为50％。 24小时胃酸度测定示Oxmetidine 400mg一日二次和甲氰咪胍250mg一日四次的效果相仿。本文的目的是比较Oxmetidine和甲氰咪胍的安全性和疗效。病例和方法
Oxmetidine (S K & F 92994) is a novel and specific histamine H 2 -receptor antagonist that inhibits both gastric acid secretion and post-challenge gastric acid secretion in healthy volunteers and patients with peptic ulcer disease. After the Impromidine-stimulated healthy individuals were given an intravenous Oxmetidine intravenous infusion, Oxmetidine was 4 times more potent than cimetidine on a milligram basis. When given orally, the two formulations were similar in potency because the oral bioavailability of Oxmetidine was about 50%. A 24-hour stomach acid measurement showed Oxmetidine 400mg twice daily and cimetidine 250mg four times a day. The purpose of this article is to compare the safety and efficacy of Oxmetidine and Cimetidine. Cases and methods