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目的本研究拟探讨洗胃治疗在苯二氮革类镇静药物中毒救治中的必要性。方法2003-01～2005-09期间53例口服正常剂量30倍以上苯二氮蕈类镇静药物中毒患者,服药时间＜5h,将其分为洗胃组和非洗胃组两组,其余常规治疗措施相同,在治疗前及治疗开始后1、2、3、6、12及24h分别进行镇静、催眠评分,并对24h后各重要脏器功能进行比较。结果非洗胃组在各时间点的镇静、催眠评分与洗胃组差异无统计学意义；在24h后各重要脏器功能评估上亦无差异；在并发症上洗胃组发生率16．0%,严重并发症4．0%,两组间差异有统计学意义(P＜0．01)。结论本研究表明,对于大量口服苯二氮(艹卓)类镇静药物中毒患者的救治,洗胃治疗在患者意识转清及重要脏器功能恢复方面并无优越性,且会产生各种并发症,因此不推荐使用。
Objective This study was to investigate the necessity of gastric lavage in the treatment of sedated benzodiazepines. Methods From January 2003 to September 2005, 53 patients with benzodiazepine sedation drug whose oral dose was more than 30 times normal were taken for less than 5 hours. The patients were divided into two groups: gastric lavage group and non-gastric lavage group. The other conventional treatment The same measures were taken before treatment and at 1,2,3,6,12 and 24 hours after treatment, respectively, sedation, hypnosis score, and 24 hours after the function of various important organs were compared. Results There was no significant difference in hypnosis score and gastric lavage group between non-gastric lavage groups at various time points. There was no difference in functional assessment of vital organs after 24 h. The incidence of complications in lavage group was 16.0 %, Severe complications 4.0%, the difference between the two groups was statistically significant (P <0.01). Conclusions This study shows that gastric lavage treatment has no superiority in clearing patients’ consciousness and restoring vital organs, and can produce various complications for the treatment of large quantities of sedated benzodiazepines. , It is not recommended to use.