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用微电泳技术研究乙酰胆碱（Ａｃｈ）及胆碱能受体阻断剂阿托品（Ａｔｒ）和六羟季胺（Ｃ６）对电刺激猫隐神经Ｃ类纤维诱发的大脑皮质体感Ⅰ区（ＳⅠ区）神经元单位放电（Ｃ－ＥＤ）的影响。结果表明，绝大部分Ｃ－ＥＤ单位（２２／２４）位于大脑皮质的深层；Ａｃｈ能明显抑制大部分单位（５／８）的Ｃ－ＥＤ，标准化互协方差函数（ＮＣＣＶＦ）积分值降低（Ｐ＜０．０５）；Ａｔｒ使大部分单位（１１／１７）的Ｃ－ＥＤ增强，ＮＣＣＶＦ积分值增加（Ｐ＜０．０５）；而Ｃ６使大部分单位（６／９）的Ｃ－ＥＤ减弱，ＮＣＣＶＦ积分值降低（Ｐ＜０．０５）。表明，Ｃ类纤维诱发的大脑皮质单位放电接受胆碱能调制，可能主要通过胆碱能Ｍ受体起抑制作用，还有胆碱能Ｎ受体的易化作用。提示Ａｃｈ在大脑皮质的神经元水平上也可能参与痛觉的调制。
To investigate the effect of Ach and cholinergic receptor blockers Atr and C6 on the somatosensory cortex Ⅰ (SⅠ) region induced by electrical stimulation of cat saphenous C fiber in rats, Effect of unit discharge (C-ED) on neurons. The results showed that the majority of C-ED units (22/24) were located in the deep layer of the cerebral cortex. Ach significantly inhibited C-ED in most units (5/8) and reduced the integral value of the standardized covariance function (NCCVF) P <0.05). Atr enhanced the C-ED in most of the patients (11/17) and increased the integral of NCCVF (P <0.05) Decreased, NCCVF integral value decreased (P <0.05). This suggests that C-typed cortical discharges in the cerebral cortex undergo cholinergic modulation that may play a major role in cholinergic M receptors and facilitation of cholinergic N-receptors. Suggesting that Ach may also participate in modulation of pain in the neurons of the cerebral cortex.