论文部分内容阅读
介绍降钙素的生产方法和临床应用,并重点探讨降钙素结构与活性的关系,为新型降钙素的设计和制备提供理论基础。以鲑鱼和人的降钙素为研究对象,分析近年来各种新型降钙素研究的数据资料,讨论影响降钙素活性的各种因素。在新型降钙素设计时,要综合考虑各种因素,既要考虑到降钙素8→22位之间两性a-螺旋形成的能力,又要考虑到它的柔顺性以及降钙素C-末端的亲水性。应用基因工程
The production method and clinical application of calcitonin are introduced. The relationship between calcitonin structure and activity is discussed emphatically, which provides the theoretical basis for the design and preparation of new calcitonin. Taking salmon and human calcitonin as the research objects, the data of various new calcitonin studies in recent years were analyzed, and various factors affecting calcitonin activity were discussed. In the design of new calcitonin, to consider a variety of factors, it is necessary to take into account the calcitonin 8 → 22 between the sex a-helix formation capacity, but also to take into account its flexibility and calcitonin C- Hydrophilic end. Application of genetic engineering