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目的 :探讨不同浓度乙醇以及在事先给予丹参提取物 F ( DSE-F)和消炎痛的情况下大鼠胃粘膜血液动力学变化。方法 :用组织反射光谱分析仪 ( TS-2 0 0 )测定胃粘膜表层血液量 ( ΔEr)和 Hb氧饱和度 ( F)。结果 :( 1)胃粘膜损伤程度随乙醇浓度增高而加大 ;( 2 )低浓度乙醇引起胃粘膜充血 ,而高浓度则导致静脉淤血 ;( 3 )乙醇诱导的胃粘膜血液动力学变化因预先给予 DSE-F或消炎痛而减轻。结论 :( 1)乙醇性胃粘膜损伤的致病因素是高浓度乙醇所致的胃粘膜淤血缺氧 ;( 2 ) DSE-F对乙醇性胃粘膜损伤的保护作用在于减轻乙醇所致的胃粘膜血液动力学变化 ,后者可能与内源性前列腺素有关。
AIM: To investigate the changes of gastric mucosal hemodynamics in rats with different concentrations of ethanol and with the prior administration of Danshen extract F (DSE-F) and indomethacin. Methods: Gastric mucosal surface blood volume (ΔEr) and Hb oxygen saturation (F) were measured by tissue reflectance spectroscopy (TS-200). Results: (1) The degree of gastric mucosal lesion increased with the increase of ethanol concentration; (2) Low concentration of ethanol caused gastric mucosal hyperemia, while high concentration caused venous congestion; (3) Ethanol-induced gastric mucosal hemodynamic changes due to prior Give DSE-F or indomethacin and reduce. Conclusion: (1) The etiological factor of ethanol-induced gastric mucosal injury is gastric mucosal congestion and hypoxia induced by high concentration of ethanol. (2) The protective effect of DSE-F on alcoholic gastric mucosal injury is to relieve the gastric mucosa caused by ethanol Hemodynamic changes, the latter may be related to endogenous prostaglandins.