论文部分内容阅读
用自行建立的大鼠内侧额叶皮层损伤和急性脑缺血再灌流损伤两种手术方法，能造成动物学习和记忆的缺陷并可作为“痴呆”模型。从手术当天起，用山莨菪碱（６５４～２）（３０ｍｇ．ｋｇ~（－１）／ｄ，ｉｐ）慢性给药共１０次。首次发现６５４－２对两种脑损害所致的动物对回避反应学习和记忆能力的下降都有改善作用。实验结果还表明，６５４－２能增强皮层损伤后前脑超氧化物岐化酶（ＳＯＤ）的活力，并抑制脂质过氧化物（ＭＤＡ）含量的升高。提示６５４－２可能有抗自由基损伤和保护脑细胞的作用。
Two kinds of surgical methods, which are used to establish the medial frontal cortex injury and acute cerebral ischemia-reperfusion injury in rats, can cause learning and memory deficits in animals and can be used as a model of “dementia.” From the day of surgery, the rats were dosed with anisodamine (654-2) (30 mg.kg -1 / d, ip) for 10 times. For the first time, it was found that 654-2 improved both learning and memory abilities of avoidance learning in animals caused by both brain lesions. The results also show that 654-2 can enhance the activity of forebrain superoxide dismutase (SOD) and inhibit the increase of lipid peroxidation (MDA) after cortical injury. Tip 654-2 may have anti-free radical damage and the role of brain cells.