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用光化学诱导大鼠皮层血栓形成并观察单线态氧清除剂组氨酸对血栓性局部脑缺血的防治效应。结果表明，光化学反应后缺血区皮层磁化率降低（Ｐ＜０．０５）、脑电（ＥＥＧ）抑制、脑水含量由８１．００±０．９５％增加到８５．７８±３．７９％（Ｐ＜０．０１）和全血血小板聚集功能明显增强（Ｐ＜０．０１）。经一次静注组氨酸溶液（５ｍｇ／ｋｇ）治疗的动物，上述各项指标与对侧或对照组比无明显差异（Ｐ＞０．０５）。证明光化学诱导的脑血栓形成与单线态氧形成、血管内皮受损有关。由于组氨酸可清除单线态氧而对脑功能具有保护作用。
Photochemical induction of rat cortical thrombosis and observation of the effect of singlet oxygen scavenger histidine on thrombotic cerebral ischemia. The results showed that the magnetic susceptibility of ischemic cortex decreased (P <0.05), EEG decreased, and the content of brain water increased from 81.00 ± 0.95% to 85.78 ± 3.79% after photochemical reaction (P <0.01) and whole blood platelet aggregation (P <0.01). After an intravenous injection of histidine solution (5mg / kg) of animals, the above indicators and contralateral or control group no significant difference (P> 0.05). It is demonstrated that photochemically-induced cerebral thrombosis is associated with singlet oxygen formation and vascular endothelial damage. Histidine clears singlet oxygen and has protective effects on brain function.