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目的:观察贝尼地平对急性心肌梗死(AMI)患者血清白细胞介素17(IL-17)和白细胞介素10(IL-10)水平的影响及其临床应用安全性分析。方法:选择AMI患者124例,将其随机分为两组:观察组62例(常规治疗+贝尼地平2mg/d)和对照组62例(仅予常规治疗),于入院当天及第3、7、14天清晨采集患者肘静脉空腹血,采用双抗体夹心酶联免疫吸附法测定血清IL-17和IL-10水平。测量并记录观察期间所有患者每日晨起静卧位血压。结果:两组患者血清IL-10水平在住院当天及第3、7、14天比较差异无统计学意义。住院期间两组患者收缩压、舒张压比较差异无统计学意义。与对照组相比,观察组血清IL-17水平在住院当天及第3天比较差异无统计学意义(P>0.05);而在第7、14天IL-17水平显著降低,有统计学差异(P<0.05)。结论:在不影响患者血压的前提下,贝尼地平可通过降低血清IL-17水平,使AMI的炎性反应更快趋于稳定。
Objective: To observe the effect of benidipine on serum interleukin 17 (IL-17) and interleukin 10 (IL-10) in patients with acute myocardial infarction (AMI) and its clinical application safety analysis. Methods: A total of 124 AMI patients were selected and divided into two groups at random: 62 cases in the observation group (routine treatment + 2mg / d) and 62 cases in the control group (conventional therapy only) Fasting blood samples were collected from elbow vein of patients on the 7th and 14th days. Serum IL-17 and IL-10 levels were measured by double antibody sandwich enzyme-linked immunosorbent assay. Measure and record all patients during the observation period morning daily supine blood pressure. Results: There was no significant difference in serum IL-10 level between the two groups on the day of hospitalization and on the 3rd, 7th and 14th day. There was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups during hospitalization. Compared with the control group, serum IL-17 level in the observation group had no significant difference on the day of hospitalization and on the third day (P> 0.05), while on the 7th and 14th days, the level of IL-17 was significantly lower (P <0.05). Conclusion: Benidipine can reduce the level of serum IL-17 and make the inflammatory response of AMI stabilize faster and faster without affecting the patient’s blood pressure.