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本文研究刀豆素A(ConA)对幼鼠日本脑炎(JE)病毒感染的作用。用ConA注入8~11天小鼠能有效地防止JE病毒造成的死亡。其保护程度取决于体内给予ConA的剂量和时间。实验用8~11天瑞士白色小鼠。病毒为P20778株JE病毒(1958年从患者脑内分离)。用JE病毒攻击以前,将400~500μg的ConA分2~3次注入动物腹腔。ConA在JE攻击前后经腹腔注入幼鼠。在猪肾细胞上用噬斑方法测定鼠器官病毒滴度。小鼠用2dex LD_(50)JE病毒腹腔内注入后观察20天。结果
This article investigates the effect of ConA on Japanese encephalitis (JE) virus infection in young rats. Injection of ConA for 8-11 days effectively prevented death from JE virus. The degree of protection depends on the dose and timing of ConA administered in vivo. Experimental 8 to 11 days Swiss white mice. The virus is the P20778 strain of JE virus (isolated from the patient’s brain in 1958). Prior to challenge with JE virus, ConA from 400 to 500 μg was injected into the abdominal cavity of the animal two to three times. ConA was injected intraperitoneally into young rats before and after JE challenge. Murine organ viral titers were determined by plaque assay on porcine kidney cells. The mice were observed for 20 days after intraperitoneal injection with 2dex LD_ (50) JE virus. result