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目的：观察康莱特注射液联合化疗治疗晚期胃癌患者的疗效及毒副反应。方法118例晚期胃癌患者随机分为两组，治疗组应用DCF方案（多西紫杉醇+顺铂+5-氟尿嘧啶）化疗加康莱特注射液200mL，静脉滴注，每日1次，连续10d为一周期，对照组应用DCF方案化疗。至少在2次化疗之后复查胸部、腹盆腔CT等影像学检查，进行近期疗效的评价，观察毒副反应和生活质量。结果治疗组有效率（55%）与对照组（51.7%）比较，差异无统计学意义（P=0.5347）。但治疗组患者生活质量明显高于对照组（P＜0.05），不良反应发生率明显低于对照组（P＜0.05）。结论康莱特注射液联合DCF方案化疗治疗晚期胃癌疗效相近，但可提高患者生活质量、降低化疗不良反应。“,”Objective To observe the effect and toxicity of Kanglaite injection combined with chemotherapy on advanced gastric cancer.Methods 118 patients with advanced gastric cancer were randomly divided into two groups. The treatment group was treated by DCF regimen(docetaxel+cisplatin+5-fluorouracil) combining with Kanglaite(200mL,iv,d1~10),and the control group was treated with DCF regimen alone.The efifcacy,side effect and quality of life were compared after two cycles of chemotherapy at least.Results The response rate of treatment group(55%) and control group(51.7%) was similar(P=0.5347).However,the quality of life in treatment group was signiifcantly higher than the control group(P<0.05),incidence of adverse reactions was signiifcantly lower than the control group(P<0.05).Conclusion Kanglaite can not enhance the effect of DCF regimen for treating advanced gastric cancer,but may improve patient’s quality of life,reduce the adverse effects of chemotherapy.