本文分析了以阿霉素为主的联合化学疗法治疗50例晚期恶性肿廇的临床疗效、毒性反应及其与给药方法、剂量的关系。本组病例总有效率达38.0％,其中乳腺癌有效率36.4％,略高于国内报告。有效率、毒副反应发生率与累积剂量成正比,局部毒性反应发生率与给药方法有关。 This article analyzed the clinical efficacy and toxicity of 50 cases of advanced malignant swollen joints treated with doxorubicin-based combined chemotherapy and its relationship with administration methods and doses. The total effective rate of this group of cases was 38.0%, of which the effective rate of breast cancer was 36.4%, slightly higher than the domestic report. The rate of occurrence of toxicity and side effects is proportional to the cumulative dose. The incidence of local toxicity is related to the method of administration.