中医对“证”的探讨已有几千年历史 ,但运用现代科学手段研究“证”本质只有几十年历史。 1986年日本学者测定不同证的血药浓度有一定差异[1],尚鲜见证与药动学(Pharmacokinetics,PK)的理论与实验文献报道。 1991年黄熙提出“证治药动学”假说[2 ]。新近方剂药动学研究迅猛[3～ The study of “certificates” by traditional Chinese medicine has a history of several thousand years, but the use of modern scientific methods to study the essence of “certificates” is only a few decades old. In 1986, Japanese scholars determined that there was a certain difference in the plasma concentration of different syndromes [1]. The theory and experimental literature of the Pharmacokinetics (PK) were still fresh and witnessed. In 1991, Huang Xi proposed the hypothesis of “study and pharmacokinetics” [2]. Recent research on pharmacokinetics of new prescriptions has been rapid [3～